Publications

Journal Articles

Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation

Published in The Journal of Clinical Investigation, 2023

This paper highlights lipid droplets as a critical and unappreciated component of endothelial cell biology, explain how lipids increase blood pressure acutely, and provide a mechanistic account for the epidemiological link between obesity and elevated blood pressure..

Recommended citation: Roberts, Emilia. (2023). "Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation." The Journal of Clinical Investigation. 133(24).
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Cell contractility and focal adhesion kinase control circumferential arterial stiffness

Published in Vascular Biology, 2022

This paper studies the effect on mechanical properties of arteries via investigating cell contractility and focal adhesion kinase protein complex.

Recommended citation: Roberts, Emilia. (2022). "Cell contractility and focal adhesion kinase control circumferential arterial stiffness." Vascular Biology. 4(1).
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Efemp1 modulates elastic fiber formation and mechanics of the extrahepatic bile duct

Published in bioRxiv, 2021

This paper examines the idea that EFEMP1 has an important role in the formation of elastic fibers and mechanical properties of the extrahepatic bile duct. These data suggest that altered expression of EFEMP1 in the extrahepatic bile duct leads to an abnormal response to mechanical stress such as obstruction, potentially explaining the role of EFEMP1 in biliary atresia.

Recommended citation: Roberts, Emilia. (2021). "Efemp1 modulates elastic fiber formation and mechanics of the extrahepatic bile duct." bioRxiv.
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RAGE antagonist peptide mitigates AGE-mediated endothelial hyperpermeability and accumulation of glycoxidation products in human ascending aortas and in a murine model of aortic aneurysm

Published in bioRxiv, 2021

This paper is about interactions extracellular-matrix and glycoxidation in the aorta and other cardiovascular structures

Recommended citation: Roberts, Emilia. (2021). "RAGE antagonist peptide mitigates AGE-mediated endothelial hyperpermeability and accumulation of glycoxidation products in human ascending aortas and in a murine model of aortic aneurysm." bioRxiv.
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Decreased vascular smooth muscle contractility in Hutchinson-Gilford Progeria Syndrome linked to defective smooth muscle myosin heavy chain expression

Published in Scientific Reports, 2021

This paper examines the relationship between Hutchinson-Gilford Progeria Syndrome and the cellular/mechanical properties of the cardiovascular system.

Recommended citation: Roberts, Emilia. (2021). "Decreased vascular smooth muscle contractility in Hutchinson-Gilford Progeria Syndrome linked to defective smooth muscle myosin heavy chain expression." Scientific Reports. 11(1).
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Arterial stiffness and cardiac dysfunction in Hutchinson-Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Published in Life Science Alliance, 2021

This paper examines a possible course of correction in treating Hutchinson-Gilford Progeria Syndrome via lysyl oxidase, resulting in a decrease in cardiac disfunction.

Recommended citation: Roberts, Emilia. (2021). "Arterial stiffness and cardiac dysfunction in Hutchinson-Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase." JLife Science Alliance. 4(5).
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Emilia Roberts